Affliction Clothing is an American clothing manufacturer based in Signal Hill, California. It is owned by Affliction Inc. who also used to run a MMA promotion Affliction Entertainment.

Affliction's clothing line includes Affliction Jeans, Affliction Boardshorts, Affliction Belts, Affliction Button Downs, Affliction Denim,Affliction Hats, Affliction T-shirts, Affliction Polo Shirts, Affliction Thermals, and Affliction hoodies. Their style has been described as "skull and crossbone inspired". Many of Affliction's shirts bear the logo of many of the world's top ranked MMA fighters, including Georges St. Pierre, Randy Couture, and Quinton Jackson.

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